THAP11
Function
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).
Sequence Similarities
Belongs to the THAP11 family.
Cellular localization
- Nucleus
- Cytoplasm
- May be regulated by shuttling of the protein between the cytoplasm and nucleus.
Alternative names
HRIHFB2206, THAP11, THAP domain-containing protein 11