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THAP12

Function

Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.

Alternative names

DAP4, P52RIPK, PRKRIR, THAP0, THAP12, 52 kDa repressor of the inhibitor of the protein kinase, p52rIPK, 58 kDa interferon-induced protein kinase-interacting protein, Death-associated protein 4, THAP domain-containing protein 0, THAP domain-containing protein 12, p58IPK-interacting protein

swissprot:O43422 entrezGene:5612 omim:607374