THBS1
GeneName
THBS1
Summary
THBS1, also known as thrombospondin-1, TSP1, or TSP, is a 129 kDa glycoprotein that is secreted into the extracellular matrix and is found at the cell surface. It plays a critical role in cell adhesion, migration, and the regulation of angiogenesis. THBS1 is involved in various biological processes including the immune response, inflammatory response, and apoptotic processes. It interacts with multiple ligands such as collagen V, fibronectin, and heparin, and binds calcium ions, which is essential for its structural and functional properties. THBS1 is expressed in various tissues and is particularly abundant in platelets and the extracellular matrix, where it contributes to tissue repair and remodeling.
Importance
THBS1 is relevant to: - Angiogenesis and tissue repair through its regulation of endothelial cell behaviour and migration - Cancer biology due to its dual role in promoting and inhibiting tumour growth and metastasis - Cardiovascular diseases as it influences platelet aggregation and vascular integrity - Inflammatory diseases where it modulates immune cell functions and responses - Neurobiology as it is involved in synaptic plasticity and neuroprotection.
Top Products
For researchers investigating THBS1, we recommend two excellent primary antibodies. The first is the well-cited Anti-Thrombospondin 1 antibody [A6.1] (ab1823), which has garnered 79 citations and is highly regarded for its performance in immunohistochemistry (IHC), immunocytochemistry (ICC), and flow cytometry (FC). This antibody is a trusted choice for those looking to study THBS1 in various applications. Additionally, we offer the recombinant antibody, Anti-Thrombospondin 1 antibody [EPR22928-10] (ab263905). This product has been validated for use in Western blotting (WB), IHC, and immunoprecipitation (IP), making it a versatile option for researchers seeking reliable detection of THBS1. With its recombinant nature, this antibody ensures batch-to-batch consistency, which is essential for reproducible results in your experiments. The Anti-Thrombospondin 1 antibody ELISA Kit (ab93653), supported by 2 citations, is an excellent option for researchers looking to accurately measure THBS1 levels in their samples.
Abcam Product Citation Summary
The data indicates that THBS1 is being studied in various contexts, including its role in human adipose-derived mesenchymal/stromal cells and angiogenesis in human endothelial cells. Additionally, THBS1 is being investigated in mouse tumor tissues, particularly in relation to macrophage infiltration, suggesting its relevance in cancer research.
Abcam Product Citation Table
Function
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:15014436, PubMed:18285447, PubMed:2430973, PubMed:6489349). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:14568985, PubMed:24511121, PubMed:29042481, PubMed:32679764). Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis (PubMed:14568985). Ligand for receptor CD47 (PubMed:19004835, PubMed:8550562). Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS (PubMed:29042481). Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 (PubMed:10613822, PubMed:11134179, PubMed:1371676). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:32679764). Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner (PubMed:29042481). Ligand for immunoglobulin-like cell surface receptor SIRPA (PubMed:24511121). Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA (PubMed:24511121). Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging (PubMed:29042481, PubMed:32679764).
Sequence Similarities
Belongs to the thrombospondin family.
Tissue Specificity
Expressed by platelets (at protein level) (PubMed:101549). Expressed by monocyte-derived immature and mature dendritic cells (at protein level) (PubMed:14568985).
Cellular localization
- Secreted
- Cell surface
- Secreted
- Extracellular space
- Extracellular matrix
- Endoplasmic reticulum
- Sarcoplasmic reticulum
- Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:101549, PubMed:6777381). Incorporated into the extracellular matrix (ECM) of fibroblasts (PubMed:6341993). The C-terminal region in trimeric form is required for retention in the ECM (PubMed:18285447). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity).
Alternative names
TSP, TSP1, THBS1, Thrombospondin-1, Glycoprotein G