THEMIS
Function
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
Post-translational modifications
Phosphorylated on Tyr residues quickly after TCR stimulation.
Sequence Similarities
Belongs to the themis family.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
C6orf190, C6orf207, THEMIS, Protein THEMIS, Thymocyte-expressed molecule involved in selection