May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity).
Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement.
Belongs to the themis family.
Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.
C1orf38, ICB1, THEMIS2, Protein THEMIS2, Induced by contact to basement membrane 1 protein, Thymocyte-expressed molecule involved in selection protein 2, Protein ICB-1
Proteins
Oncology
72049Da
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ab236975