THEMIS2
Function
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity).
Post-translational modifications
Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement.
Sequence Similarities
Belongs to the themis family.
Tissue Specificity
Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
C1orf38, ICB1, THEMIS2, Protein THEMIS2, Induced by contact to basement membrane 1 protein, Thymocyte-expressed molecule involved in selection protein 2, Protein ICB-1