THPO

Domain

Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.

Function

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

Involvement in disease

Thrombocythemia 1

THCYT1

A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the EPO/TPO family.

Cellular localization

• Secreted

Alternative names

• Thrombopoietin
• C-mpl ligand
• Megakaryocyte colony-stimulating factor
• Megakaryocyte growth and development factor
• Myeloproliferative leukemia virus oncogene ligand
• ML
• MGDF
• MGDF
• THPO

Database links

• entrezGene:7066
• omim:600044
• swissprot:P40225

Target type

Proteins

Molecular weight

37823Da