THRAP3
Function
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Post-translational modifications
ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.
Sequence Similarities
Belongs to the BCLAF1/THRAP3 family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
- Nucleus
- Nucleoplasm
- Nucleus speckle
Alternative names
BCLAF2, TRAP150, THRAP3, Thyroid hormone receptor-associated protein 3, BCLAF1 and THRAP3 family member 2, Thyroid hormone receptor-associated protein complex 150 kDa component, Trap150