Thyroid hormone-inducible hepatic protein
Function
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.
Sequence Similarities
Belongs to the SPOT14 family.
Tissue Specificity
Mainly expressed in tissues that synthesize triglycerides.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
Thyroid hormone-inducible hepatic protein, Spot 14 protein, S14, SPOT14, THRSP