Thyroid peroxidase
Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Pathway
Hormone biosynthesis; thyroid hormone biosynthesis.
Post-translational modifications
Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface (By similarity).
Cleaved in its N-terminal part.
Sequence Similarities
Belongs to the peroxidase family. XPO subfamily.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Thyroid peroxidase, TPO, Tpo