Thyroid peroxidase
Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Involvement in disease
An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Thyroid dyshormonogenesis 2A
TDH2A
A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
None
The disease is caused by variants affecting the gene represented in this entry.
Pathway
Hormone biosynthesis; thyroid hormone biosynthesis.
Post-translational modifications
Glycosylated.
Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.
Sequence Similarities
Belongs to the peroxidase family. XPO subfamily.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Isoform 3
- Cell surface
Alternative names
Thyroid peroxidase, TPO