tig
Domain
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
Function
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Sequence Similarities
Belongs to the FKBP-type PPIase family. Tig subfamily.
Cellular localization
- Cytoplasm
- About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Alternative names
E2348C_0371, tig, Trigger factor, TF, PPIase