TIGIT

Domain

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Function

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Tissue specificity

Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

• T-cell immunoreceptor with Ig and ITIM domains
• V-set and immunoglobulin domain-containing protein 9
• V-set and transmembrane domain-containing protein 3
• VSTM3
• TIGIT
• VSIG9

Database links

• entrezGene:201633
• omim:612859
• swissprot:Q495A1

Target type

Proteins

Primary research area

Immuno-oncology

Other research areas

• Immunology & Infectious Disease

Molecular weight

26319Da