TIMP2
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Post-translational modifications
The activity of TIMP2 is dependent on the presence of disulfide bonds.
Sequence Similarities
Belongs to the protease inhibitor I35 (TIMP) family.
Cellular localization
- Secreted
Alternative names
Metalloproteinase inhibitor 2, CSC-21K, Tissue inhibitor of metalloproteinases 2, TIMP-2, TIMP2