WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity).
Phosphorylated. PAX5 binding increases phosphorylation.
Ubiquitinated by XIAP/BIRC4.
Belongs to the WD repeat Groucho/TLE family.
In all tissues examined, mostly in brain, and muscle.
GRG4, KIAA1261, TLE4, Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4
Proteins
Developmental Biology
83755Da
We found 2 products in 2 categories
ab64833
ab152750