TLE5
Domain
Lacks the C-terminal WD repeats.
Function
Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Post-translational modifications
Ubiquitinated by XIAP/BIRC4.
Sequence Similarities
Belongs to the WD repeat Groucho/TLE family.
Tissue Specificity
Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
Cellular localization
- Nucleus
Alternative names
AES, GRG, GRG5, TLE5, TLE family member 5, Amino-terminal enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, Amino enhancer of split