TLR1

Function

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Sequence Similarities

Belongs to the Toll-like receptor family.

Tissue Specificity

Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Cytoplasmic vesicle
• Phagosome membrane
• Single-pass type I membrane protein
• Membrane raft
• Golgi apparatus
• Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.

Alternative names

CD281, KIAA0012, TLR1, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein, TIL

Database links

swissprot:Q15399 omim:601194 entrezGene:7096

Other research areas

• Immuno-oncology