TMED9
Function
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.
Post-translational modifications
N-linked glycosylated containing high mannose.
Sequence Similarities
Belongs to the EMP24/GP25L family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein
- Golgi apparatus
- cis-Golgi network membrane
- Single-pass type I membrane protein
- Endoplasmic reticulum-Golgi intermediate compartment membrane
- Single-pass type I membrane protein
- Golgi apparatus
- trans-Golgi network membrane
- Single-pass type I membrane protein
- Cycles between compartments of the early secretatory pathway.
Alternative names
GP25L2, TMED9, Transmembrane emp24 domain-containing protein 9, GMP25, Glycoprotein 25L2, p24 family protein alpha-2, p25, p24alpha2