Tmem119
Developmental stage
Highly expressed in early and late stage osteoblasts of developing embryos (at protein level).
Function
Plays an important role in bone formation and normal bone mineralization (PubMed:20025746, PubMed:22416756, PubMed:26207632). Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746, PubMed:22416756, PubMed:22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed:26207632).
Tissue Specificity
Expressed in spermatocytes and spermatids in the developing testis (at protein level). Expressed in the brain, heart, lung, spleen, skeletal muscle, ovary, testis and epididymis (PubMed:26207632). Predominantly expressed in osteoblasts (PubMed:20025746).
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Cytoplasm
- Endoplasmic reticulum membrane
- Secreted
Alternative names
Transmembrane protein 119, Osteoblast induction factor, OBIF, Tmem119