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TMEM119

Developmental stage

Highly expressed in early and late stage osteoblasts of developing embryos (at protein level).

Function

Plays an important role in bone formation and normal bone mineralization (PubMed:26207632, PubMed:22416756, PubMed:20025746). Promotes the differentiation of myoblasts into osteoblasts (PubMed:22416756, PubMed:20025746, PubMed:22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Upregulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed:26207632).

Tissue specificity

Expressed in spermatocytes and spermatids in the developing testis (at protein level). Expressed in the brain, heart, lung, spleen, skeletal muscle, ovary, testis and epididymis (PubMed:26207632). Predominantly expressed in osteoblasts (PubMed:20025746).

Cellular localization

  • Cell membrane
  • Single-pass type I membrane protein
  • Cytoplasm
  • Endoplasmic reticulum membrane

Alternative names

  • Transmembrane protein 119
  • Osteoblast induction factor
  • OBIF
  • Tmem119

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

29401Da