TMEM119

Highly expressed in early and late stage osteoblasts of developing embryos (at protein level).

Plays an important role in bone formation and normal bone mineralization (PubMed:20025746, PubMed:22416756, PubMed:26207632). Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746, PubMed:22416756, PubMed:22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed:26207632).

Expressed in spermatocytes and spermatids in the developing testis (at protein level). Expressed in the brain, heart, lung, spleen, skeletal muscle, ovary, testis and epididymis (PubMed:26207632). Predominantly expressed in osteoblasts (PubMed:20025746).

• Cell membrane
• Single-pass type I membrane protein
• Cytoplasm
• Endoplasmic reticulum membrane
• Secreted

Transmembrane protein 119, Osteoblast induction factor, OBIF, Tmem119

• entrezGene:231633
• swissprot:Q8R138

Proteins

Neuroscience

29401Da