TMEM135
Developmental stage
Up-regulated in bone marrow-derived mesenchymal stem cells during differentiation into adipocytes compared to osteoblasts.
Function
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.
Sequence Similarities
Belongs to the TMEM135 family.
Cellular localization
- Mitochondrion membrane
- Multi-pass membrane protein
- Peroxisome membrane
- Multi-pass membrane protein
Alternative names
Transmembrane protein 135, Peroxisomal membrane protein 52, PMP52, TMEM135