TMEM14B
Function
Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.
Sequence Similarities
Belongs to the TMEM14 family.
Tissue Specificity
Mainly expressed in the outer subventricular zone (OSVZ) of the fetal brains.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
Transmembrane protein 14B, TMEM14B