TMEM205
Function
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
Sequence Similarities
Belongs to the TMEM205 family.
Tissue Specificity
Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).
Cellular localization
- Membrane
- Multi-pass membrane protein
- Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.
Alternative names
UNQ501/PRO1018, TMEM205, Transmembrane protein 205