TMEM205

In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

Belongs to the TMEM205 family.

Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).

• Membrane
• Multi-pass membrane protein
• Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.

UNQ501/PRO1018, TMEM205, Transmembrane protein 205

• entrezGene:374882
• omim:613771
• swissprot:Q6UW68

Proteins

21198Da