TMEM25

Function

In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.

Tissue Specificity

Expressed throughout the brain with higher levels in the pyramidal cell layer of the hippocampal CA1 and CA3 regions. Also highly expressed within the hippocampal dentate gyrus region and cerebellum and in scattered neurons in the cerebral cortex.

Cellular localization

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Isoform 4
• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Secreted
• Isoform 3
• Secreted
• Late endosome
• Lysosome

Alternative names

UNQ2531/PRO6030, TMEM25, Transmembrane protein 25

Database links

swissprot:Q86YD3 omim:613934 entrezGene:84866