TMEM25

In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.

Expressed throughout the brain with higher levels in the pyramidal cell layer of the hippocampal CA1 and CA3 regions. Also highly expressed within the hippocampal dentate gyrus region and cerebellum and in scattered neurons in the cerebral cortex.

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Isoform 4
• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Secreted
• Isoform 3
• Secreted
• Late endosome
• Lysosome

UNQ2531/PRO6030, TMEM25, Transmembrane protein 25

• entrezGene:84866
• omim:613934
• swissprot:Q86YD3

Proteins

39285Da