TMEM30B
Function
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.
Sequence Similarities
Belongs to the CDC50/LEM3 family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
CDC50B, TMEM30B, Cell cycle control protein 50B, P4-ATPase flippase complex beta subunit TMEM30B, Transmembrane protein 30B