TMEM59
Domain
The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.
Function
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:23376921, PubMed:27273576). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the TMEM59 family.
Cellular localization
- Late endosome membrane
- Single-pass type I membrane protein
- Lysosome membrane
- Single-pass type I membrane protein
- Cell membrane
- Single-pass type I membrane protein
- Golgi apparatus membrane
- Single-pass type I membrane protein
- Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.
Alternative names
C1orf8, HSPC001, UNQ169/PRO195, TMEM59, Transmembrane protein 59, Liver membrane-bound protein