TMF1
Domain
The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Function
Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).
Post-translational modifications
Phosphorylated by FER.
Cellular localization
- Cytoplasm
- Nucleus
- Golgi apparatus membrane
- Concentrated at the budding structures localized at the tips of cisternae.
Alternative names
ARA160, TMF1, TATA element modulatory factor, TMF, Androgen receptor coactivator 160 kDa protein, Androgen receptor-associated protein of 160 kDa