TMOD1
Function
Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
Sequence Similarities
Belongs to the tropomodulin family.
Tissue Specificity
Highly expressed in the erythrocyte, heart and skeletal muscle.
Cellular localization
- Cytoplasm
- Cytoskeleton
- In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574, PubMed:38168645).
Alternative names
D9S57E, TMOD, TMOD1, Tropomodulin-1, Erythrocyte tropomodulin, E-Tmod