TMPO
Domain
The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
The C-terminal domain forms a four-stranded coiled coil.
Function
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.
TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Post-translational modifications
Phosphorylated in a mitose-specific manner.
Sequence Similarities
Belongs to the LEM family.
Tissue Specificity
Expressed in many tissues. Most abundant in adult thymus and fetal liver.
Cellular localization
- Nucleus
- Chromosome
- Expressed diffusely throughout the nucleus.
Alternative names
LAP2, TMPO, Thymopoietin isoform alpha, Thymopoietin-related peptide isoform alpha, TP alpha, TPRP isoform alpha