TMPO

Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.

Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.

Citrullinated by PADI4.

Belongs to the LEM family.

Expressed in many tissues. Most abundant in adult thymus and fetal liver.

• Nucleus inner membrane
• Single-pass type II membrane protein
• Tightly associated with the nuclear lamina.
• Isoform Zeta
• Cytoplasm

LAP2, TMPO, Thymopoietin-related peptide isoforms beta/gamma, TP beta/gamma, TPRP isoforms beta/gamma

• entrezGene:7112
• omim:188380
• swissprot:P42167
• swissprot:P42166

Proteins