TMPO

Domain

Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.

Function

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.

Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Post-translational modifications

Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.

Citrullinated by PADI4.

Sequence Similarities

Belongs to the LEM family.

Tissue Specificity

Expressed in many tissues. Most abundant in adult thymus and fetal liver.

Cellular localization

• Nucleus inner membrane
• Single-pass type II membrane protein
• Tightly associated with the nuclear lamina.
• Isoform Zeta
• Cytoplasm

Alternative names

LAP2, TMPO, Thymopoietin-related peptide isoforms beta/gamma, TP beta/gamma, TPRP isoforms beta/gamma

Database links

swissprot:P42167 entrezGene:7112 swissprot:P42166 omim:188380