TMPRSS11A
Function
Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
ECRG1, HATL1, HESP, TMPRSS11A, Transmembrane protease serine 11A, Airway trypsin-like protease 1, Epidermal type-II transmembrane serine protease, Esophageal cancer-susceptibility gene 1 protein