TMPRSS15
Function
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Involvement in disease
Enterokinase deficiency
ENTKD
Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
Intestinal brush border.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
ENTK, PRSS7, TMPRSS15, Enteropeptidase, Enterokinase, Serine protease 7, Transmembrane protease serine 15