TMPRSS4
Function
Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity).
(Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.
Post-translational modifications
Proteolytically processed; probably by an autocatalytic mechanism.
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract (PubMed:10825129). Coexpressed with ACE2 within mature enterocytes (PubMed:32404436).
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Transmembrane protease serine 4 catalytic chain
- Secreted
- Activated by cleavage and secreted.
Alternative names
TMPRSS3, UNQ776/PRO1570, TMPRSS4, Transmembrane protease serine 4, Channel-activating protease 2, Membrane-type serine protease 2, CAPH2, MT-SP2