TMPRSS4

Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity).

(Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.

Proteolytically processed; probably by an autocatalytic mechanism.

Belongs to the peptidase S1 family.

High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract (PubMed:10825129). Coexpressed with ACE2 within mature enterocytes (PubMed:32404436).

• Cell membrane
• Single-pass type II membrane protein
• Transmembrane protease serine 4 catalytic chain
• Secreted
• Activated by cleavage and secreted.

TMPRSS3, UNQ776/PRO1570, TMPRSS4, Transmembrane protease serine 4, Channel-activating protease 2, Membrane-type serine protease 2, CAPH2, MT-SP2

• entrezGene:56649
• omim:606565
• swissprot:Q9NRS4

Proteins

Oncology

48246Da