TMSB4X
Function
Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398).
Hemoregulatory peptide AcSDKP
Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).
Post-translational modifications
Hemoregulatory peptide AcSDKP
AcSDKP is inactivated by ACE, which removes the dipeptide Lys-Pro from its C-terminus.
Sequence Similarities
Belongs to the thymosin beta family.
Tissue Specificity
Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.
Cellular localization
- Cytoplasm
- Cytoskeleton
Alternative names
TB4X, THYB4, TMSB4, TMSB4X, Thymosin beta-4, T beta-4, Fx