TMX3
Domain
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Function
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (PubMed:15623505). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:31304984).
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the protein disulfide isomerase family.
Tissue Specificity
Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver, prostate, placenta, eye and muscle.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
Alternative names
KIAA1830, TXNDC10, TMX3, Protein disulfide-isomerase TMX3, Thioredoxin domain-containing protein 10, Thioredoxin-related transmembrane protein 3