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Tnc

Developmental stage

At 11.5 dpc, expressed in maxillary process (at protein level) (PubMed:14709716). Expressed in the stomach and periosteum of the ribs at 14.5 and 15.5 dpc (at protein level) (PubMed:14709716). Expressed in developing bones such as the mandible, palate and teeth at 16.5 dpc (at protein level) (PubMed:14709716). Expressed in the smooth muscle layer of the stomach and mesenchyme of the lung at 16.5 dpc (at protein level) (PubMed:22654117).

Isoform 2

Expressed in the intestine at 13 dpc (PubMed:1703162). Expressed in the cerebrum, cerebellum and stomach at 17 dpc and at 6 days of age (PubMed:1717349). Expression spreads to the duodenum, ileum, colon, bladder and skeletal muscle at 6 days of age (PubMed:1717349). Expressed in the kidney at birth (PubMed:1703162).

Isoform 5

Expressed in the cerebellum at 17 dpc, expression is decreased at 6 days of age (PubMed:1717349). Expressed in the thymus, stomach and weakly in skeletal muscle at 17 dpc (PubMed:1717349). Expressed in the intestine at birth (PubMed:1703162). Expressed in the thymus, stomach, duodenum, ileum, colon, bladder and skeletal muscle at 6 days of age (PubMed:1717349). Expressed in the kidney at 2 weeks of age (PubMed:1703162). Expressed in the thymus and colon at 32 days of age (PubMed:1717349).

Function

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).

Post-translational modifications

N-glycosylated.

Sequence Similarities

Belongs to the tenascin family.

Tissue Specificity

Expressed in the corneal limbus, the periosteum and the rib molecular layer of the cerebellum, the matrix of kidney tubules, blood vessels, stomach and intestine (at protein level).

Isoform 2

Weakly expressed in the brain.

Isoform 5

Highly expressed in the thymus and moderately expressed in the brain.

Cellular localization

Alternative names

Hxb, Tnc, Tenascin, TN, Hexabrachion, Tenascin-C, TN-C

swissprot:Q80YX1 entrezGene:21923 swissprot:Q80YX0 swissprot:Q148T5 swissprot:Q148T4