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TNFRSF10B

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Involvement in disease

Squamous cell carcinoma of the head and neck

HNSCC

A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

None

The disease may be caused by variants affecting the gene represented in this entry.

Post-translational modifications

(Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.

Tissue specificity

Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

Cellular localization

  • Membrane
  • Single-pass type I membrane protein

Alternative names

  • Tumor necrosis factor receptor superfamily member 10B
  • Death receptor 5
  • TNF-related apoptosis-inducing ligand receptor 2
  • TRAIL receptor 2
  • TRAIL-R2
  • TRICK2
  • TNFRSF10B
  • DR5
  • KILLER
  • TRAILR2
  • UNQ160/PRO186
  • ZTNFR9

Target type

Proteins

Primary research area

Oncology

Molecular weight

47878Da