Tnfrsf10b
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Post-translational modifications
(Microbial infection) Glycosylated at Arg-293 by S.typhimurium protein Ssek3.
Tissue Specificity
Highly expressed in heart, lung and kidney.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD262, Dr5, Killer, Tnfrsf10b, Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, MK