Tnfrsf12a

Function

Receptor for TNFSF12/TWEAK (By similarity). Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Tissue Specificity

Highly expressed in fetal heart, intestine, kidney, liver, lung and skin, and in adult heart and ovary. Intermediate expression in adult kidney, lung and skin.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD266, Fgfrp2, Fn14, Tnfrsf12a, Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein 14, Fibroblast growth factor-regulated protein 2, Tweak-receptor, FGF-inducible 14, TweakR

Database links

swissprot:Q9CR75 entrezGene:27279

Other research areas

• Immunology & Infectious Disease