TNFRSF12A

Function

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Tissue Specificity

Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD266, FN14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, FGF-inducible 14, TweakR

Database links

swissprot:Q9NP84 entrezGene:51330 omim:605914

Other research areas

• Immunology & Infectious Disease