Tnfrsf13c
Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Involvement in disease
Defects in Tnfrsf13c are a cause of severe B-cell deficiency. B-cell deficient strain A/WySnJ has a 4.7 kb insertion in the BAFFR gene leading to an altered C-terminus. The mutant RNA is not detectable. B-cell lymphopoiesis is normal, but the life span of peripheral B-cells is much reduced.
Tissue Specificity
Highly expressed in spleen and testis; detected at lower levels in lung and thymus.
Cellular localization
- Membrane
- Single-pass type III membrane protein
Alternative names
CD268, Baffr, Bcmd, Br3, Tnfrsf13c, Tumor necrosis factor receptor superfamily member 13C, B-cell maturation defect, B-cell-activating factor receptor, BAFF receptor, BLyS receptor 3, BAFF-R