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TNFRSF14

OverviewProducts

Domain

The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with BY55 and BTLA.

Function

Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity).

(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.

(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.

Post-translational modifications

N-glycosylated.

Sequence similarities

Belongs to the tumor necrosis factor receptor superfamily.

Tissue specificity

Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044).

Cellular localization

  • Cell membrane
  • Single-pass type I membrane protein

Alternative names

  • Tumor necrosis factor receptor superfamily member 14
  • Herpes virus entry mediator A
  • Tumor necrosis factor receptor-like 2
  • Herpesvirus entry mediator A
  • HveA
  • TR2
  • UNQ329/PRO509
  • TNFRSF14
  • HVEA
  • HVEM

Database links

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

30392Da