Tnfrsf17

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Expressed in mature B-cells, but not in T-cells or monocytes.

• Cell membrane
• Single-pass type III membrane protein
• Endomembrane system
• Single-pass type III membrane protein
• Perinuclear Golgi-like structures.

CD269, BCM, BCMA, TNFRSF17, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein

• entrezGene:608
• omim:109545
• swissprot:Q02223

Proteins

Immuno-oncology

20165Da