Tnfrsf18
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).
Tissue Specificity
Preferentially expressed in activated T lymphocytes.
Cellular localization
- Isoform A
- Cell membrane
- Single-pass type I membrane protein
- Isoform B
- Cell membrane
- Single-pass type I membrane protein
- Isoform C
- Cell membrane
- Single-pass type I membrane protein
- Isoform D
- Secreted
Alternative names
CD357, Gitr, Tnfrsf18, Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein