TNFRSF18

Function

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Tissue specificity

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

Cellular localization

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Secreted

Alternative names

• AITR
• GITR
• UNQ319/PRO364
• AITR
• GITR
• TNFRSF18
• UNQ319/PRO364
• Tumor necrosis factor receptor superfamily member 18
• Activation-inducible TNFR family receptor
• Glucocorticoid-induced TNFR-related protein

Database links

• entrezGene:8784
• omim:603905
• swissprot:Q9Y5U5

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

26000Da