TNFRSF1A
GeneName
TNFRSF1A
Summary
TNFRSF1A, also known as TNFR1, p55, or p60, is a 50kDa transmembrane receptor that is predominantly expressed on the surface of various cell types, including immune cells and endothelial cells. It is a member of the tumour necrosis factor receptor superfamily and is primarily localised to the plasma membrane and extracellular region. TNFRSF1A plays a crucial role in mediating the effects of tumour necrosis factor (TNF), activating multiple intracellular signalling pathways such as the JAK-STAT pathway, NF-kappaB signalling, and apoptotic pathways. This receptor is involved in various biological processes, including inflammation, apoptosis, and cellular responses to mechanical stimuli.
Importance
TNFRSF1A is relevant to: - Inflammatory diseases due to its role in mediating pro-inflammatory responses and cytokine signalling - Cancer research as it influences apoptosis and can affect tumour progression - Cardiovascular health through its involvement in cardiac muscle hypertrophy and valve development - Immune responses, particularly in defence against bacterial infections and regulation of endothelial barriers
Top Products
For researchers investigating TNFRSF1A, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-TNF Receptor I antibody (ab223352), which has garnered 15 citations and is highly regarded for its performance in Western blotting (WB), immunohistochemistry (IHC), and immunocytochemistry (ICC). This product is a trusted choice for those looking to study TNFRSF1A in various applications. Additionally, we offer the recombinant antibody, Anti-TNF Receptor I antibody [EPR23742-65] (ab259817), which has been validated in knockout models and is suitable for Western blotting (WB). With its monoclonal nature, this antibody ensures batch-to-batch consistency, making it an ideal option for researchers seeking reliable TNFRSF1A detection. The Recombinant Human TNFRSF1A Protein (Active) ELISA Kit (ab283448) is an excellent option for researchers looking to measure TNFRSF1A with confidence.
Abcam Product Citation Summary
The data indicates that TNFRSF1A is being studied in the context of necroptosis in human umbilical vein endothelial cells and in relation to inflammation and epithelial barrier dysfunction in rats. The use of western blotting across different studies highlights the importance of this target in understanding various biological processes.
Abcam Product Citation Table
Domain
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Involvement in disease
Periodic fever, familial, autosomal dominant
FPF
A hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
None
The disease is caused by variants affecting the gene represented in this entry.
Multiple sclerosis 5
MS5
A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry. An intronic mutation affecting alternative splicing and skipping of exon 6 directs increased expression of isoform 4 a transcript encoding a C-terminally truncated protein which is secreted and may function as a TNF antagonist.
Post-translational modifications
The soluble form is produced from the membrane form by proteolytic processing.
(Microbial infection) Glycosylated at Arg-376 by enteropathogenic E.coli protein NleB1 and S.typhimurium protein Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Golgi apparatus membrane
- Single-pass type I membrane protein
- Secreted
- A secreted form is produced through proteolytic processing.
- Isoform 4
- Secreted
- Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
Alternative names
CD120a, TNFAR, TNFR1, TNFRSF1A, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, p55, p60, TNF-R1, TNF-RI, TNFR-I
Database links
swissprot:P19438 entrezGene:7132 entrezGene:21937 omim:191190
Other research areas
- Immunology & Infectious Disease
- Oncology