TNFRSF1B

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Phosphorylated; mainly on serine residues and with a very low level on threonine residues.

A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Secreted
• Tumor necrosis factor-binding protein 2
• Secreted

CD120b, TNFBR, TNFR2, TNFRSF1B, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, TNF-R2, TNF-RII, TNFR-II

• entrezGene:7133
• omim:191191
• swissprot:P20333

Proteins

Immunology & Infectious Disease

• Immuno-oncology
• Oncology

48291Da