TNFRSF1B
GeneName
TNFRSF1B
Summary
TNFRSF1B, also known as p75, TNF R2, or TNFR2, is a 48 kDa receptor that belongs to the tumor necrosis factor receptor superfamily. It is primarily expressed in the extracellular region and is localised to the plasma membrane, including membrane rafts and specific granule membranes. TNFR2 binds to tumor necrosis factor (TNF) and plays a role in various signalling pathways, including extrinsic and intrinsic apoptotic signalling, inflammatory responses, and regulation of immune cell functions. This receptor is involved in the modulation of glial cell-neuron signalling and has a significant impact on cardiac muscle hypertrophy and myelination processes.
Importance
TNFRSF1B is relevant to: - Immune modulation and inflammation through its role in TNF-mediated signalling pathways that regulate cytokine production and T cell activity - Neuroinflammatory diseases, as it is involved in the regulation of neuroinflammatory responses and myelination - Cardiac health, due to its negative regulation of cardiac muscle hypertrophy - Developmental processes, including aortic and pulmonary valve development, highlighting its role in morphogenesis and tissue integrity
Top Products
For researchers investigating TNFRSF1B, we recommend the well-cited Anti-TNF Receptor II antibody [MR2-1] (ab8161). This monoclonal antibody is particularly effective for flow cytometry (FC) and immunocytochemistry (ICC), making it a reliable choice for various experimental setups. With 9 citations, it demonstrates a solid reputation within the research community, highlighting its effectiveness in studying TNFRSF1B. The Recombinant Human TNF Receptor II protein ELISA Kit (ab157266) is an excellent option for researchers looking to measure TNFRSF1B in their experiments.
Abcam Product Citation Summary
The data indicates that the Abcam antibody ab8161 has been consistently used to detect TNFRSF1B in immunohistochemistry applications specifically within the context of mouse breast cancer tissue. This suggests a focus on understanding the role of TNFRSF1B in breast cancer pathology.
Abcam Product Citation Table
Function
Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity.
Post-translational modifications
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass type I membrane protein
- Isoform 2
- Secreted
- Tumor necrosis factor-binding protein 2
- Secreted
Alternative names
CD120b, TNFBR, TNFR2, TNFRSF1B, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, TNF-R2, TNF-RII, TNFR-II
Database links
Other research areas
- Immuno-oncology
- Oncology