TNFRSF25
Function
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Post-translational modifications
(Microbial infection) Glycosylated at Arg-352 by enteropathogenic E.coli protein NleB1.
Glycosylated.
Tissue Specificity
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass type I membrane protein
- Isoform 2
- Cell membrane
- Single-pass type I membrane protein
- Isoform 9
- Cell membrane
- Single-pass type I membrane protein
- Isoform 11
- Cell membrane
- Single-pass type I membrane protein
- Isoform 3
- Secreted
- Isoform 4
- Secreted
- Isoform 5
- Secreted
- Isoform 6
- Secreted
- Isoform 7
- Secreted
- Isoform 8
- Secreted
- Isoform 10
- Secreted
- Isoform 12
- Secreted
Alternative names
APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779, TNFRSF25, Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, LARD