TNFRSF4

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.

(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

Involvement in disease

Immunodeficiency 16

IMD16

An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.

None

The disease is caused by variants affecting the gene represented in this entry.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD134, TXGP1L, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor

Database links

swissprot:P43489 entrezGene:7293 omim:600315

Other research areas

• Immunology & Infectious Disease