TNFRSF8
GeneName
TNFRSF8
Summary
TNFRSF8, also known as CD30 or Ki-1 antigen, is a 64kDa transmembrane protein primarily expressed on activated T and B lymphocytes. It is localised to the plasma membrane and plays a pivotal role in mediating cell signalling through its interaction with its ligand, CD153. TNFRSF8 is involved in various biological processes, including the positive regulation of apoptotic pathways and the production of tumour necrosis factor (TNF). Additionally, it participates in cellular responses to mechanical stimuli and signal transduction pathways, influencing immune responses and cell proliferation.
Importance
TNFRSF8 is relevant to: - The regulation of immune responses, particularly in the context of T cell activation and differentiation - The pathogenesis of lymphomas and other malignancies due to its role in cell survival and proliferation - Therapeutic targeting in cancer immunotherapy, given its involvement in apoptosis and TNF production - Understanding autoimmune diseases, as it may influence the balance between immune activation and tolerance
Top Products
For researchers investigating TNFRSF8, we highly recommend the top-selling recombinant antibody, Anti-CD30 antibody [EPR4102] (ab134080). This antibody has been validated for use in immunohistochemistry (IHC) and western blotting (WB), making it a versatile choice for various experimental needs. With 5 citations, it has garnered attention in the research community, reflecting its reliability and effectiveness in detecting CD30. This recombinant antibody offers the added benefit of batch-to-batch consistency, ensuring dependable results in your studies. The Recombinant Human TNFL8 Protein ELISA Kit (ab283923) is an excellent option for researchers looking to measure TNFRSF8 in their experiments.
Abcam Product Citation Summary
The use of the Abcam antibody ab134080 for TNFRSF8 in Western blot analysis highlights its relevance in cancer research, particularly in human cancer cells. This suggests a potential role of TNFRSF8 in cancer biology.
Abcam Product Citation Table
Function
Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).
Post-translational modifications
Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832).
Sequence Similarities
Belongs to the TNFR8 family.
Tissue Specificity
Isoform 2
Detected in alveolar macrophages (at protein level).
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass type I membrane protein
- Isoform 2
- Cytoplasm
Alternative names
CD30, D1S166E, TNFRSF8, Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30
Database links
swissprot:P28908 entrezGene:943 omim:153243
Other research areas
- Immunology & Infectious Disease