Tnfrsf9

Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).

Immunodeficiency 109 with lymphoproliferation

IMD109

An autosomal recessive primary immune disorder characterized by recurrent sinopulmonary infections, susceptibility to infection with Epstein-Barr virus (EBV), persistent EBV viremia, and EBV-induced lymphoproliferation or B-cell lymphoma.

None

The disease may be caused by variants affecting the gene represented in this entry.

Expressed on the surface of activated T-cells.

• Cell membrane
• Single-pass type I membrane protein

CD137, ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA

• entrezGene:3604
• omim:602250
• swissprot:Q07011

Proteins

Immuno-oncology

27899Da