TNFRSF9
GeneName
TNFRSF9
Summary
TNFRSF9, also known as CD137 or ILA, is a 28kDa transmembrane protein that is primarily expressed on the surface of activated T cells and other immune cells. It functions as a signalling receptor, playing a crucial role in the regulation of T cell activation and proliferation. TNFRSF9 is localised to the plasma membrane, where it participates in the apoptotic process and modulates the proliferation of immature T cells in the thymus. Through its interactions with ligands, it influences various immune responses and contributes to the overall homeostasis of the immune system.
Importance
TNFRSF9 is relevant to: - Immunotherapy strategies, particularly in enhancing T cell responses against tumours through its role in T cell activation - Autoimmune diseases, as its modulation can affect the balance of T cell populations - The understanding of T cell development in the thymus, which is crucial for effective immune responses - Apoptotic mechanisms, providing insights into cell death pathways and their implications in cancer and other diseases
Top Products
For researchers investigating TNFRSF9, we recommend two primary antibodies that cater to different experimental needs. The first is the well-cited polyclonal antibody, Anti-CD137 antibody (ab197942), which is particularly effective for immunohistochemistry (IHC) and has garnered 5 citations, reflecting its reliability in the field. Additionally, we offer the recombinant antibody, Anti-CD137 antibody [EPR20238] (ab209256), which is validated for use in Western blotting (WB). This recombinant option provides the advantage of batch-to-batch consistency, making it an excellent choice for those requiring dependable results in their experiments. The Recombinant Human CD137 protein (Active) ELISA Kit (ab287936) is an excellent option for researchers looking to measure TNFRSF9 in their experiments.
Abcam Product Citation Summary
The data indicates that TNFRSF9 is being investigated in the context of antitumor efficacy, particularly in an adoptive cell transfer (ACT) immunotherapy model using mouse models. This suggests a focus on the role of TNFRSF9 in cancer therapies.
Abcam Product Citation Table
Function
Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).
Involvement in disease
Immunodeficiency 109 with lymphoproliferation
IMD109
An autosomal recessive primary immune disorder characterized by recurrent sinopulmonary infections, susceptibility to infection with Epstein-Barr virus (EBV), persistent EBV viremia, and EBV-induced lymphoproliferation or B-cell lymphoma.
None
The disease may be caused by variants affecting the gene represented in this entry.
Tissue Specificity
Expressed on the surface of activated T-cells.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD137, ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA